Santiago is an interesting city! As a Latina from the U.S the culture is definitely different then what I was used to. Nonetheless, there are warm people who will be willing to help you. I found this in my host mom who is an amazing woman that I still remain in contact with today. The city itself can be a little overwhelming to get used to with all the bus routes and subway system but once you master the systems you can travel to different parts of Santiago with ease.
If the city life doesn't appeal to you have no worries because there are a number of parks and hiking trails close by. One of the things I enjoyed the most about my time in Santiago, Chile was ironically leaving the city and exploring different parts of Chile and South America as a whole.
A tip I have is to do your research on pre-paid phones when abroad as I know this was a challenge for many students on my trip. When I was abroad WOM was the most economical and reliable for phone service.